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Impact of PEEP on Respiratory Effort During Assisted Ventilation

RecruitingNAAges 18 Years - anyAllPontificia Universidad Catolica de Chile
NCT07437846 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Assisted mechanical ventilation is widely used to preserve diaphragmatic activity and improve lung aeration in patients with acute respiratory failure. However, during assisted ventilation, excessive inspiratory effort may develop and contribute to lung injury, diaphragmatic overload, and patient self-inflicted lung injury. Optimizing ventilator settings to modulate respiratory effort therefore represents a major physiological and clinical challenge. Positive end-expiratory pressure (PEEP) is a key determinant of lung recruitment and respiratory system mechanics and may influence inspiratory effort by modifying lung volume, compliance, and respiratory drive. Despite its widespread use, PEEP titration in clinical practice is still mainly guided by oxygenation parameters, while its direct effects on inspiratory effort during assisted mechanical ventilation remain insufficiently character

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📋 Eligibility rules (as published)
Inclusion criteria: * Age ≥18 years. * ICU patients receiving invasive mechanical ventilation (endotracheal tube or tracheostomy). * Ventilated in an assisted mode with spontaneous breathing * Clinically stable to undergo protocolized PEEP changes. * Sedation level compatible with spontaneous breathing and ventilator triggering * Informed consent from the patient or legally authorized representative. Exclusion Criteria: * Contraindication to esophageal balloon placement (if applicable). * Significant hemodynamic instability or unstable vasopressor requirements. * Unstable arrhythmia or active myocardial ischemia. * Undrained pneumothorax or major air leak. * Controlled ventilation without effective spontaneous effort (apnea, neuromuscular blockade, deep sedation). * Pregnancy * Acute or chronic neurological conditions that may impair respiratory drive or interfere with the regulation of spontaneous breathing.
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What it tests

  • PEEP Level Adjustment
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Where

1 site
Hospital Clinico UC
Santiago, Chile
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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