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Influence of Physical Exercise on Neuroplasticity and Sensorimotor Networks in Older Adults

RecruitingNAAges 20 Years - 80 YearsAllUniversite du Littoral Cote d'Opale
NCT07438808 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to investigate the influence of a single session of moderate aerobic exercise on motor cortex neuroplasticity in older adults, both alone and in combination with transcranial direct current stimulation (tDCS), and to compare these effects with those observed in young adults. Normal aging is associated with changes in the central nervous system that can affect motor function, sensorimotor integration, and cortical inhibitory mechanisms. These alterations may reduce the brain's capacity for neuroplasticity, which is essential for motor learning and functional adaptation. Physical exercise has been proposed as a potential strategy to counteract age-related decline in neuroplasticity. In this study, healthy young and older adults will participate in three experimental sessions. Participants will complete two experimental conditions in a randomized crossover des

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men or women aged 20 to 35 for the younger group and 65 to 80 for the older group. * Healthy right-handed or left-handed subjects. * Subjects who have signed an informed consent form. * Ability to understand spoken and written French to follow study procedures. * Subjects affiliated with or beneficiaries of a social security system. Exclusion Criteria: * History of psychaitric disorders : individuals with mental retardation or severe impairment of cognitive, behavioral, or emotional functions that prevent them from understanding the protocol and signing the informed consent form. * Neurological history (epilepsy, stroke, brain or spinal cord surgery, and history of neurological diseases affecting motor skills and sensitivity, such as multiple sclerosis, neurodegenerative diseases such as Parkinson's or Alzheimer's). * Inability to give informed consent (e.g., dementia, significant hearing impairment, insufficient language proficiency). * Contraindications to TMS and tDCS : uncontrolled epilepsy, intracranial metallic foreign body, hearing aid or cochlear implant, implanted stimulator or pump, scalp skin lesion, high intracranial pressure, cerebrospinal fluid shunt). * Presence of a cardiac pacemaker or other implanted electronic medical device. * Use of psychotropic drugs. * Individuals under legal guardianship or curatorship. * Pregnant and breastfeeding women. * Inability or recognized contraindication to physical activity.
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What it tests

  • Aerobic Exercise
  • Physical Inactivity
  • Transcranial Magnetic Stimulation
  • transcranial direct current stimulation
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Where

1 site
Eurasport
Loos, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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