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Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.

Recruitingn/aAges 18 Years - anyAllUniversity Hospital, Ghent
NCT07438938 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Out-of-hospital cardiac arrest (OHCA) is a leading cause of death worldwide. Despite constantly improving resuscitation techniques, the chances of survival remain limited. During cardiopulmonary resuscitation (CPR), a closure of the airway may occur, impeding ventilation. This phenomenon also complicates the interpretation of the end-tidal CO2 (ETCO2) in the capnogram. The extent to which airway closure occurs is quantified by the Airway Opening Index (AOI). This can be calculated from the capnogram and is seen as a measure of the quality of CPR applied as well as a possible indicator to predict the outcome of CPR. In this study, we analyse capnogram data from approximately 150 cases, collected during interventions for OHCA and logged in the Lazarus database (UZ Gent and AZORG) to answer three research questions below: 1. What is the prevalence of AOI during CPR? 2. Is there a correlat

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult (over 18 years old) patients with out-of-hospital cardiac arrest. * Patients undergoing cardiopulmonary resuscitation (CPR). * Patients who were intubated and had available capnogram recordings immediately after intubation. Exclusion Criteria: * Patients that were not intubated * Patients that did not receive CPR following intubation * Cases with a technical challenge with the ETCO₂ measurement (i.e., issues with waveform data of the capnogram.
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What it tests

  • Not listed
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Where

1 site
Ghent University Hospital
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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