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A Study of TORL-5-700 in Relapsed/Refractory Non Hodgkin's Lymphoma

RecruitingPhase 1, Phase 2Ages 18 Years - anyAllTORL Biotherapeutics, LLC
NCT07439653 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A Phase 1/2 study to evaluate safety, tolerability, and anticancer activity of TORL-5-700 as a monotherapy and in combination in R/R NHL

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📋 Eligibility rules (as published)
Inclusion Criteria: * Confirmed B-NHL, including but not limited to de novo DLBCL; FL, Grades 1 to 3A; MCL; transformed lymphoma (tFL, RT) and FL Grade 3B; MZL and MALT. * Eastern Cooperative Oncology Group (ECOG) performance status less than or equal to 2. * At least 1 measurable lesion per Lugano criteria. * Tumor tissue is available. * Adequate organ function Exclusion Criteria: * T-cell lymphoma * CLL or SL * Burkitt lymphoma and high-grade B-cell lymphoma * CNS involvement * Peripheral neuropathy \> Grade 2 * Uncontrolled medical conditions * Viral infections
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What it tests

  • TORL-5-700
  • TORL-5-700 at MTD/RP2D
  • TORL-5-700 at MTD/RP2D in combination with another agent
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Where

9 sites
Providence Medical Foundation
Fullerton, United States
Cancer and Blood Specialty Clinic, Los Alamitos
Los Alamitos, United States
UCLA
Santa Monica, United States
Stanford University
Stanford, United States
University of California Miami, Sylvester Comprehensive Cancer Center
Miami, United States
University of Iowa Health Care
Iowa City, United States
Cancer Center of Kansas, Wichita
Wichita, United States
Sarah Cannon Research Institute
Nashville, United States

…and 1 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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