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NUTRIMOOD-Inflammation and Depressive Comorbidity in Obesity: Modulation by Omega-3 Polyunsaturated Fatty Acids Status

RecruitingNAAges 18 Years - 54 YearsAllNational Science and Technology Council, Taiwan
NCT07439744 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A 12-week, randomized, placebo-controlled trial testing the efficacy of n-3 PUFA treatment (EPA, 2 g/day) in alleviating depressive symptoms in a subgroup of obese subjects with comorbid depression and low n-3 PUFA status (n-3 index \< 8%) (81), from the Taiwanese cohort. Associations with PLA2/COX2 genotypes, lifestyle, nutritional profiles and gut microbiota will also be determined.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Major depressive disorder. * Antidepressant drug-free. Exclusion Criteria: * Schizophrenia * Mania * Anxiety disorders (except for social phobia and generalized anxiety that are often comorbid with MDD) * Obsessive-compulsive disorder * Post-traumatic stress disorder * Alcohol or drug abuse/dependence (except for nicotine) * Active suicidal ideation * Serious medical/neurological conditions, especially requiring corticosteroid/non-steroidal anti-inflammatory or immunosuppressive therapies or chronic thyroid hormone replacement
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What it tests

  • Eicosapentaenoic acid (omega-3 fatty acid)
  • Placebo
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Where

1 site
Mind Body Interface Research Center (MBI Lab & Care)
Taichung, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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