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Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section

RecruitingNAAges 18 Years - 45 YearsFemaleNigde Omer Halisdemir University
NCT07440667 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery. Although intraoperative fluid administration is routinely used to prevent spinal-induced hypotension, the optimal fluid strategy remains unclear. Both restrictive and liberal fluid approaches may influence maternal hemodynamics and postoperative outcomes through different physiological mechanisms. This prospective, single-center, randomized controlled trial aims to compare restrictive (≤3 mL/kg/h) and liberal (\>3 mL/kg/h) intraoperative crystalloid fluid strategies in patients undergoing elective cesarean section under spinal anesthesia. The primary outcome is the incidence of PONV within the first 24 hours postoperatively. Secondary outcomes include postdural punctur

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📋 Eligibility rules (as published)
Inclusion Criteria: * Female patients aged 18-45 years * ASA physical status II * Scheduled for elective cesarean section under spinal anesthesia * Provision of written informed consent Exclusion Criteria: * Emergency cesarean section * Preeclampsia or eclampsia * Known cardiac failure * Known renal failure * Known hepatic failure * Coagulopathy * Contraindication to spinal anesthesia * Conversion to general anesthesia * Major technical complications during spinal anesthesia * Refusal to participate
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What it tests

  • Restrictive intraoperative crystalloid fluid strategy (≤3 mL/kg/h)
  • Liberal intraoperative crystalloid fluid strategy (>3 mL/kg/h)
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Where

1 site
Niğde Ömer Halisdemir University Hospital
Niğde, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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