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โ† Trials
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Effects of Smoking on Network Connectivity in Patients With Schizophrenia Symptoms in Scz Patients

RecruitingNAAges 18 Years - anyAllThe Hong Kong Polytechnic University
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In plain words

What the trial is, and whether it could suit you

The prevalence of smoking among people with schizophrenia (SCZ) is substantially higher at 54% to 90% (McClave et al., 2010). About half of all deaths amongst people with scz are attributed to smoking-related diseases and cancer involving the lung, the cardiovascular system, and the liver (Kely et al., 2011; WHO, 2019). Acceptance and commitment therapy (ACT) is effective for treating psychotic symptoms and addictive behaviours. In a local randomised controlled trial comparing individual ACT to social support for smoking cessation in adult scz smokers, the self-reported quit rates in ACT group were higher than in the social support group (6 months: 12.3% vs. 7.7%, p=0.56 ; 12 months: 10.8% vs. 7.7%, p=0.76; Mak, Loke, and Leung, 2021). In this study, functional neuroimaging (fMRI) will be combined with symptoms assessment in order to ascertain whether group-based ACT is effective in modi

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Individuals who have been diagnosed with schizophrenia or schizoaffective disorder and after at least one-year followup; * currently taking anti-psychotic medications for โ‰ฅ 3 months with good compliance; * aged 18 years or above; * able to communicate in Cantonese Exclusion Criteria: * Have any other current or past psychotic disorders; * with fleeting or actual suicidal/self-harm ideations, or acting-out behavior in the past; * with a known history of violence/aggression and a forensic history * Categorized with special care or intensive care (e.g., arson, battery, physical assault, rape, murder, etc.) * Have a lifetime history of substance abuse and/or are currently receiving treatment for substance abuse (e.g., opioids, cocaine, marijuana, or stimulants); * With alcohol consumption exceeding 25 standard drinks/week for men and 20 standard drinks/week for women over the last 6 months; * Have received a diagnosis of alcohol or drug dependence in the year preceding recruitment; * Are pregnant, breast-feeding, or planning a pregnancy for the duration of the study; * Have a history or current diagnosis of attention-deficit hyperactivity disorder (ADHD); * Have a history of epilepsy or a seizure disorder; * Experience disorientation, have developmental disabilities, and/or an organic mental disorder; * fMRI-related exclusion criteria promulgated by University Research Facility in Behavioural and Systems Neuroscience (UBSN), PolyU
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What it tests

  • Acceptance and Commitment Therapy (ACT-SC)
  • 5A model (Ask, Assess, Advice, Assist & Arrange) smoking cessation intervention (5A-SC)
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Where

5 sites
Lok Hong Integrated Community Centre for Mental Wellness, Tung Wah Group of Hospitals
Hong Kong, Hong Kong
Mental Health and Development, Christian Family Service Centre
Hong Kong, Hong Kong
Out-patient Clinic (Psy), Pamela Youde Nethersole Eastern Hospital
Hong Kong, Hong Kong
The Mental Health Association of Hong Kong
Hong Kong, Hong Kong
The Society of Rehabilitation and Crime Prevention
Hong Kong, Hong Kong
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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