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Perioperative Sepsis. An Epigenetic Perspective

Recruitingn/aAges 18 Years - anyAllCarol Davila University of Medicine and Pharmacy
NCT07442552 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This single-center, prospective, observational study evaluates the impact of perioperative sepsis on inflammatory response, coagulation abnormalities, cardiac dysfunction, and microRNA expression in adult patients undergoing major abdominal surgery. Forty patients are enrolled and classified into septic and non-septic groups according to international sepsis definitions based on SOFA score criteria. Clinical, biochemical, echocardiographic, and molecular parameters, including selected microRNAs, are assessed preoperatively and within the first 24 hours postoperatively. The study aims to characterize pathophysiological differences associated with perioperative sepsis and to explore the potential prognostic value of microRNAs as early biomarkers of postoperative sepsis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years * Undergoing major abdominal surgery (elective or emergency) * Ability to provide written informed consent * Availability of biological samples in the preoperative period and within 24 hours postoperatively * Preoperative hemodynamic stability Exclusion Criteria: * Surgical reintervention within 3 months after the index procedure * Multiple surgical procedures during the same hospitalization * Active chronic infections (HIV, active viral hepatitis, tuberculosis) * Autoimmune or systemic inflammatory diseases * Chronic immunosuppressive therapy or long-term corticosteroid use * Severe hepatic failure (Child-Pugh class C) * End-stage renal disease requiring dialysis * Severe pre-existing cardiac disease (NYHA class III-IV heart failure) * Pregnancy * Refusal or inability to provide informed consent
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What it tests

  • • Presepsin • C-reactive protein (CRP) • Fibrinogen • Aspartate aminotransferase (AST) • Alanine aminotransferase (ALT) • Creatinine • Urea • Creatine kinase (CK) • Creatine kinase-MB (CK-MB) • NT-pro
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Where

1 site
Institutul Clinic Fundeni
Bucharest, Romania
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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