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Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS

RecruitingPhase 2Ages 18 Years - anyAllThe Cleveland Clinic
NCT07442747 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and brain activity in these individuals. Parkinson's disease is a progressive condition that impacts both movement and cognitive function. Previous research suggests aerobic exercise can improve PD symptoms, but the mechanisms underlying the improvement are not fully understood. This study aims to evaluate the neural (brain) mechanisms underlying exercise.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Clinical diagnosis of Parkinson's disease * Previous placement of bilateral Medtronic Percept DBS as standard of care treatment for PD * Clinically optimized DBS parameters for one month prior to enrollment * Ability to ambulate with or without an assistive device for 5 continuous minutes * Willingness to withhold antiparkinsonian medication and DBS stimulation for outcomes assessments * Medical clearance for moderate-high intensity exercise given by treating physician or physician extender Exclusion Criteria: * Neurocognitive impairment that compromises the ability to provide informed consent * Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) * A musculoskeletal issue (arthritis, osteoporosis, back problem) that would limit one's ability to engage in exercise * Current cardiac arrhythmia
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What it tests

  • Exercise
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Where

1 site
Cleveland Clinic
Cleveland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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