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The Association Between Preoperative HbA1c Levels and Postoperative Acute Kidney Injury in Isolated Coronary Artery Bypass Surgery

Recruitingn/aAges 18 Years - anyAllOsman Sila Aydin
NCT07445997 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Renal complications are frequently encountered in cardiac surgery and constitute significant causes of morbidity and mortality. They most commonly present in the form of acute kidney injury (AKI). The etiological factors of AKI include hemodynamic alterations, hemolysis and pigment nephropathy, inflammatory response and cytokine storm, ischemia-reperfusion injury, use of nephrotoxic agents, patient-related risk factors (advanced age, diabetes mellitus, preoperative renal insufficiency, congestive heart failure, hypertension, anemia), duration of surgery, and postoperative complications such as low cardiac output syndrome, sepsis, bleeding and reoperation, hypoalbuminemia, and fluid imbalance. Previous studies have demonstrated several mechanisms through which elevated HbA1c levels may contribute to acute renal injury, including glomerular damage and hyperfiltration, endothelial dysfunct

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing isolated elective CABG surgery * Patients with available preoperative and postoperative Doppler RRI measurements * Patients with available HbA1c data Exclusion Criteria: * Patients with chronic kidney disease * Emergency surgeries * Redo/revision surgeries * Patients undergoing concomitant valve surgery * Presence of acute infection or sepsis * Advanced heart failure (EF \<30%) * Requirement for intra-aortic balloon pump, pacemaker, or mechanical circulatory support * History of nephrectomy or single kidney * Preoperative serum creatinine \>2.0 mg/dL * Pregnancy * Refusal to participate in the study
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What it tests

  • Not listed
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Where

1 site
University of Health Sciences, Bursa Yuksek Ihtisas Training & Research Hospital
Bursa, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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