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A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use

RecruitingPhase 3Ages 18 Years - 65 YearsAllVanda Pharmaceuticals
NCT07446439 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Body Mass Index ≥ 25 and \< 40 kg/m\^2 * No serious medical problems or chronic diseases, specifically no type I or type II diabetes Exclusion Criteria: * Another disorder that contributes to gastrointestinal symptoms * History of intolerance and/or hypersensitivity to NK-1 receptor antagonists * History of intolerance and/or hypersensitivity to GLP-1 receptor agonists * Exposure to any investigational medication within the past 60 days
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What it tests

  • Tradipitant
  • Placebo
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Where

10 sites
Vanda Investigational Site
Los Angeles, United States
Vanda Investigational Site
San Diego, United States
Vanda Investigational Site
San Jose, United States
Vanda Investigational Site
Tampa, United States
Vanda Investigational Site
Hamilton, United States
Vanda Investigational Site
New York, United States
Vanda Investigational Site
Syosset, United States
Vanda Investigational Site
Plano, United States

…and 2 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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