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Evaluation of Revitalization Success Using i-PRF in Non-Surgical Root Canal Retreatment

RecruitingNAAges 18 Years - 50 YearsAllMarmara University
NCT07448571 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this randomized controlled clinical trial is to determine whether regenerative endodontic treatment can improve healing outcomes in teeth with apical periodontitis following failed root canal treatment. The study includes adult patients who require non-surgical root canal retreatment due to persistent periapical lesions. The main questions it aims to answer are: Does regenerative endodontic treatment improve periapical healing compared with conventional non-surgical root canal retreatment? Does regenerative treatment increase long-term treatment success and tooth survival? Researchers will compare conventional non-surgical root canal retreatment with regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) to see if the regenerative approach results in better clinical and radiographic outcomes. Participants will: Be randomly assigned to receive eith

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 50 years. * Single-rooted maxillary anterior teeth with closed apices. * Presence of periapical lesion confirmed radiographically. * Previously treated root canal tooth requiring non-surgical retreatment. * Tooth has not previously undergone non-surgical root canal retreatment. * Tooth is considered restorable. * Patient is systemically healthy. * Patient is willing to participate and provides informed consent. Exclusion Criteria: * Teeth without radiographic evidence of periapical lesion. * Teeth with developmental anomalies. * Patients with systemic diseases that may affect healing. * Pregnant patients. * Teeth presenting with internal or external root resorption.
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What it tests

  • Non-Surgical Root Canal Retreatment
  • Regenerative Endodontic Treatment
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Where

1 site
Marmara University
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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