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PENG Block and Delirium After Hip Arthroplasty

RecruitingNAAges 75 Years - 100 YearsAllPoznan University of Medical Sciences
NCT07449468 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Postoperative delirium is a common and serious complication in older adults undergoing total hip arthroplasty, associated with prolonged hospitalization, increased morbidity, delayed rehabilitation, and long-term cognitive decline. Modifiable perioperative risk factors include uncontrolled postoperative pain, opioid consumption, impaired early mobilization, and systemic inflammatory response. The Pericapsular Nerve Group (PENG) block is a regional anesthesia technique targeting the sensory innervation of the anterior hip capsule and may provide effective analgesia while preserving motor function. Improved pain control and opioid reduction may decrease the incidence of postoperative delirium. This prospective, randomized, parallel-group controlled trial aims to evaluate whether the addition of ultrasound-guided PENG block to spinal anesthesia reduces the incidence of postoperative delir

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 75 years * Scheduled for elective primary total hip arthroplasty * Planned spinal anesthesia * ASA physical status II-III * Ability to provide written informed consent * Ability to communicate and reliably assess pain using the Numeric Rating Scale (NRS) * Expected postoperative hospitalization ≥ 72 hours Exclusion Criteria: * Pre-existing delirium, acute psychosis, or active major psychiatric disorder * Documented severe dementia or inability to provide informed consent * Severe hearing or visual impairment preventing reliable CAM assessment * Contraindications to regional anesthesia (e.g., coagulopathy according to institutional standards, infection at the injection site, allergy to local anesthetics) * Pre-existing neurological deficits of the operative lower limb are interfering with assessment * Chronic opioid use (\>30 mg morphine milligram equivalents per day for \>2 weeks prior to surgery) * Severe renal impairment (eGFR \<30 mL/min/1.73 m²) * Severe hepatic insufficiency * Participation in another interventional clinical trial within 30 days * Any other condition that, in the investigator's judgment, may interfere with study participation or protocol adherence
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What it tests

  • sham block with 0.9% sodium chloride
  • 0.2% ropivacaine
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Where

1 site
Poznan University of Medical Sciences
Poznan, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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