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Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome

Recruitingn/aAges 18 Years - anyAllBicetre Hospital
NCT07450846 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute respiratory distress syndrome (ARDS) is an inflammatory injury of the lungs caused by various serious illnesses, such as a bacterial or viral lung infection. It is treated by artificial ventilation with the application of positive pressure. Pulmonary injury, coupled with artificial ventilation, can lead to right heart failure which hinders the ejection of blood to the pulmonary circulation. Modern mechanical ventilation modalities have reduced the frequency ("incidence") of this right heart failure in acute respiratory distress syndrome. A large-scale study has shown this a few years ago. However, the evolution of right heart failure during artificial ventilation, and the consequences it has on the patient's cardiovascular status are poorly determined. This study is conducted to improve knowledge in this area. In adult patients hospitalized in intensive care presenting acute respir

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years old * Hospitalization in intensive care undergoing mechanical ventilation * Presence of ARDS according to the current consensus definition (Berlin definition) * Performance of at least one echocardiography during the first 24 hours of treatment, between the 2nd and 3rd day, between the 5th and 7th day, and within 48 hours of extubation Exclusion Criteria: Pregnancy Poor echogenicity preventing reliable measurement of the dimensions of the right and left ventricles.
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What it tests

  • Not listed
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Where

1 site
Chu de Bicêtre, AP-HP
Le Kremlin-Bicêtre, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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