🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

RecruitingNAAges 50 Years - 80 YearsAllNational University of Singapore
NCT07451496 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based o

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Age 50-80 years (both male and female) * Relatively healthy and in stable health condition * Not engaged in regular resistance or aerobic training in the past 12 months (i.e., untrained) * VO₂peak below the 75th percentile for age- and sex-specific norms * Cognitive performance below 75th percentile on the NIH Toolbox Cognitive Function Battery * Willing and able to comply with exercise and supplementation protocols * English-literate (can read and understand English) * Provides written informed consent * Deemed to have mental capacity, as assessed by the Principal Investigator * Are able to attend all research visits for screening and research data collection at MD11, Yong Loo Lin School of Medicine, National University of Singapore Exclusion Criteria: * Significant change in medication in the past 3 months * History of major cardiovascular disease (e.g., coronary artery disease, heart failure, stroke) * More than two unstable chronic conditions (e.g., hypertension, diabetes, osteoarthritis, COPD) * Known allergies to soy, shellfish/seaweed, mushrooms, or supplement ingredients * Participation in another interventional clinical trial * Current use of any study-related supplement unless willing to stop * Any medical, psychiatric, or cognitive condition deemed by the PI to jeopardise safety or compliance * Pregnant or planning pregnancy during the study period * Any conditions deemed by PI that jeopardize the safety or study compliance
💊

What it tests

  • Sleep and dietary counseling
  • Supervised exercise and exergaming program
  • Motivational interviewing
  • Whey protein
  • Creatine Monohydrate
📍

Where

1 site
MD11 Clinical Research Centre, #03-01, 10 Medical Drive, Singapore 117597
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy