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Effectiveness of Small-Quantity vs Medium-Quantity Lipid-Based Nutrient Supplements for Prevention of Undernutrition in Young Children

RecruitingNAAges 26 Weeks - 33 WeeksAllAga Khan University
NCT07451951 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nutrition is essential for a child's growth, brain development, and protection from disease. While breastmilk provides the best nutrition for young infants, children older than six months may not get all the nutrients they need from breastmilk and regular foods alone. For this reason, some children receive special nutrient supplements to support healthy growth. Lipid-based nutrient supplements (LNS) are one type of supplement that provides important vitamins and minerals. These supplements are used in many countries to help prevent undernutrition in young children. In Pakistan, the government-led multisectoral nutrition program under the social safety net program currently provides medium-quantity LNS to children starting at six months of age. However, it is not known whether a smaller-quantity LNS could provide similar benefits for children in this age group from under-resourced commun

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📋 Eligibility rules (as published)
Inclusion Criteria: * Children aged 6 months (26 weeks) to 7 months and 15 days (33 weeks) with weight-for-length z-score (WLZ) ≥ -2 standard deviation (SD) and mid-upper arm circumference (MUAC) ≥125 mm, born to mothers who are beneficiaries of the Benazir Income Support Programme and registered with the Benazir Nashonuma Programme (BNP) at any point during their pregnancy. * Permanent residents of the selected districts, with no plan to relocate or migrate within the next 6 months. * Written informed consent provided by the child's caregivers. Exclusion Criteria: * Children with moderate acute malnutrition (MAM), defined as WLZ ≥ -3 to \< -2 SD, or MUAC ≥115 mm to \<125 mm. * Children with severe acute malnutrition (SAM), defined as WLZ \< -3 SD or MUAC \<115 mm or presence of bilateral pitting edema, who require therapeutic feeding. * Children with known congenital anomalies, chronic illness, or conditions affecting growth or feeding (for example, cerebral palsy or congenital heart disease). * Children already enrolled in any nutritional supplementation other than BNP or another clinical trial. * Children whose families will be unwilling to provide informed consent, or likely to be unavailable for follow-up.
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What it tests

  • Medium-quantity lipid-based nutrient supplement (MQ-LNS)
  • Small-quantity lipid-based nutrient supplement (SQ-LNS)
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Where

2 sites
BNP Facilitation Centers
Peshawar, Pakistan
BNP Facilitation Centers
Dadu, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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