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Impact of Pringle Maneuver on Postoperative Gallbladder Diseases After Hepatectomy

Recruitingn/aAges 18 Years - 85 YearsAllWest China Hospital
NCT07452848 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The liver is an organ with a rich blood supply. During liver surgery (hepatectomy), surgeons often temporarily clamp the blood vessels supplying the liver to maintain a clear surgical field and reduce bleeding. This common technique is known as the Pringle maneuver. However, this maneuver also temporarily cuts off the blood supply to the gallbladder. Currently, doctors debate whether to routinely remove a healthy gallbladder during liver surgery to prevent future gallbladder problems, or to preserve it. The primary purpose of this multicenter retrospective cohort study is to evaluate whether using the Pringle maneuver during liver surgery increases the risk of patients developing gallbladder diseases (such as gallstones or inflammation) later on. Researchers will review the past medical records of patients who underwent liver surgery with their gallbladder preserved between January 2012

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📋 Eligibility rules (as published)
Inclusion Criteria: * Aged 18 to 85 years. * Definitive diagnosis of hepatic solid lesions confirmed by imaging (such as CT, MRI, or ultrasound) and/or pathology. * Underwent elective hepatectomy with gallbladder preservation. * Preoperative liver function evaluated as Child-Pugh class A or B. * Preoperative American Society of Anesthesiologists (ASA) physical status classification of I, II, or III. Exclusion Criteria: * Preoperative evaluation indicating pre-existing biliary tract diseases (e.g., cholelithiasis, biliary inflammation, neoplastic lesions). * History of previous upper abdominal surgery. * Application of non-hepatic inflow occlusion methods during surgery (e.g., hemihepatic vascular occlusion, selective segmental vascular occlusion). * Personal history of long-term use of hormone replacement therapy, somatostatin and its analogues, or oral contraceptives. * Loss to follow-up or missing critical data postoperatively.
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What it tests

  • Pringle maneuver
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Where

8 sites
The First Affiliated Hospital of University of Science and Technology of China
Hefei, China
Xinqiao Hospital of Army Medical Universit
Chongqing, China
Sun Yat-sen University Cancer Center
Guangzhou, China
Zhujiang Hospital of Southern Medical University
Guangzhou, China
The First Affiliated Hospital of Harbin Medical University
Harbin, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Nanjing Drum Tower Hospital
Nanjing, China
Tianjin Medical University Cancer Institute and Hospital
Tianjin, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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