AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Prefrontal Theta Burst Stimulation to Improve Cognitive Impairment After ICU Delirium

RecruitingNAAges 50 Years - 75 YearsAllUniversity of Florida
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

Many older adults who survive a stay in the intensive care unit (ICU) experience delirium, a sudden change in attention and awareness caused by serious illness. Although delirium may resolve before hospital discharge, many survivors continue to experience ongoing problems with memory, attention, processing speed, and executive function (such as planning, organizing, and multitasking). These cognitive difficulties can interfere with daily activities and may increase long-term risk for cognitive decline. Currently, there are no proven treatments specifically designed to improve thinking and attention after ICU delirium. This study is testing whether a noninvasive form of brain stimulation called intermittent theta burst stimulation (iTBS) is safe, feasible, and potentially helpful for improving cognitive function in older ICU survivors who previously experienced delirium. iTBS is a patter

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Eligible individuals must have experienced an ICU admission with documented delirium (confirmed via documented Confusion Assessment Method for the ICU score12 \[CAM-ICU\] or Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition13(p5) \[DSM-5\] criteria) * Age 50 to 75 years old * 3 months post-ICU discharge at time of enrollment (defined as within 90 ยฑ 14 days) * English fluency * Family or close friend for collateral * Community-dwelling status * Montreal Cognitive Assessment14 score between 18 and 25. Exclusion Criteria: * Diagnosis of mild cognitive impairment or dementia (prior to delirium episode) * Seizure disorder * Other significant neurologic disease (e.g., Parkinson's, Huntington's, Normal pressure hydrocephalus, tumor, progressive supranuclear palsy, multiple sclerosis, hematomas, traumatic or anoxic brain injury) * Structural CT/MRI with evidence of infection or other clinically significant focal lesions (cortical strokes not large enough to distort anatomy and/or multiple lacunar infarctions โ‰ค 1.5cm and/or extensive white matter disease are allowed) * Unstable or decompensated cardiac disease (e.g., \<3 months myocardial infarction, unstable angina, decompensated congestive heart failure NYHA class 3-4) * Pacemaker * Cochlear implants * Implanted medication pumps * Intracranial metal implants * Previous TMS treatment * Pregnancy (negative urine or serum b-HCG or history of prior surgical sterilization or post-menopausal status \[12 months or more of amenorrhea\]) * Current depressive disorder (Beck Depression Inventory score15 \<13) * History of suicide attempts * Schizophrenia * Bipolar disorder * Alcohol or substance abuse * Severe visual/hearing impairment. * Informant Questionnaire on Cognitive Decline in the Elderly16 (IQCODE) score โ‰ฅ3.4 (suggesting prior cognitive decline)
๐Ÿ’Š

What it tests

  • Intermittent theta burst stimulation
  • Sham
๐Ÿ“

Where

1 site
University of Florida Shands Hospital
Gainesville, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy