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Effect Of Different Sodium Hypochlorite Concentrations On Intracanal Substance P, CGRP And Opiorphin Levels And Postoperative Pain During Root Canal Retreatment

RecruitingNAAges 18 Years - 65 YearsAllKEZBAN MELTEM ÇOLAK
NCT07453576 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This randomized clinical study aims to evaluate the effect of different sodium hypochlorite concentrations (1%, 2.5%, and 5.25%) used during root canal retreatment on intracanal levels of Substance P, CGRP, and Opiorphin, as well as postoperative pain. Patients requiring non-surgical root canal retreatment will be randomly assigned to one of three irrigation concentration groups. Intracanal samples will be collected before and after irrigation to measure neuropeptide levels. Postoperative pain will be assessed using a visual analog scale (VAS) at predetermined time intervals. The results of this study may help clarify the relationship between irrigant concentration, inflammatory mediators, and postoperative pain following root canal retreatment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged between 18 and 65 years. * Systemically healthy individuals (ASA I or II) * Patients requiring non-surgical root canal retreatment of a previously treated permanent tooth * Patients who provide written informed consent. Exclusion Criteria: * Patients with systemic diseases that may affect pain perception or inflammatory response. * Use of analgesics, anti-inflammatory drugs, or antibiotics within 7 days prior to treatment. * Pregnant or lactating women. * Teeth with root fractures, perforations, advanced periodontal disease, or non-restorable teeth. * Teeth with open apices or immature root development. * Presence of acute apical abscess with swelling or sinus tract. * Patients with known allergy to sodium hypochlorite. * Inability to achieve adequate isolation with rubber dam. * Patients unable to attend follow-up or complete pain assessment forms.
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What it tests

  • Sodium Hypochlorite 1% Irrigation
  • Sodium Hypochlorite 2.5% Irrigation
  • Sodium Hypochlorite 5% Irrigation
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Where

1 site
Atatürk University Faculty of Dentistry, Department of Endodontics
Erzurum, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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