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Investigating Subcortical Contributions to Speech Sequencing in Deep Brain Stimulator Recipients

RecruitingNAAges 18 Years - anyAllBoston University Charles River Campus
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In plain words

What the trial is, and whether it could suit you

This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech sequences. Participants will include two groups: 1. individuals with Parkinson's disease who have deep brain stimulation (DBS) devices targeting the STN and 2. individuals with essential tremor who have DBS devices targeting the VIM. Participants will complete speech tasks involving the learning and repetition of novel sound sequences. During some parts of the study, DBS stimulation will be temporarily turned on or off in a controlled research setting. This will allow researchers to examine how stimulation affects both the learning of new speech sequences and the production of previously learned sequences. All STN participants and most VIM participants will also be equ

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Native speakers of American English * Adults at least 18 years of age * A clinically established diagnosis of Parkinson's disease or essential tremor * Able to provide informed consent in the judgment of the investigator * Treated with deep brain stimulation of the subthalamic nucleus (Parkinson's disease) or ventral intermediate nucleus of the thalamus (essential tremor) * Stable Parkinson's disease or essential tremor medication regimen for at least one month * Stable DBS program settings for at least one month * Nominal DBS system function, including normal impedances at therapeutic DBS contacts, and adequate battery life or adequate IPG charging status for therapy * For DBS sensing, implanted with Medtronic Percept PC or Percept RC implantable pulse generator * Corrected vision adequate to easily read text presented during speech motor task Exclusion Criteria: * Cognitive impairment (Montreal Cognitive Assessment (MoCA; Nesreddine et al., 2005) score \< 25) or active psychotic or behavioral symptoms that would, in the judgment of the investigator, preclude proper participation in the study * Hearing impairment that interferes with accurate perception of the speech motor learning stimulus (25dB hearing level threshold at 500, 1k, 2k, and 4kHz frequencies) * Language impairment (aphasia) or speech articulation impairment (dysarthria) that precludes performance of the speech motor learning task * Neurological disorder that interferes with speech motor learning * Inability to tolerate symptoms when DBS is off * Orthodontia or atypical oral structure (e.g., cleft palate) that interferes with speech * Pregnancy * For participants in the sub-syllabic sequence learning study (Study C.2.1), experience with the following languages: Hebrew, Polish, Lithuanian, Romanian, Georgian, Tepehua, Hungarian, and Pima
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What it tests

  • Phoneme sequence learning
  • Cessation and re-enabling of stimulation of the STN
  • Cessation and re-enabling of stimulation of the VIM thalamic nucleus
  • Multisyllabic sequence learning
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Where

2 sites
Boston University
Boston, United States
Massachusetts General Hospital
Boston, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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