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โ† Trials
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Triple Antihypertensive Medication After Intracerebral Hemorrhage for Blood Pressure Control

RecruitingNAAges 18 Years - anyAllThe University of Hong Kong
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In plain words

What the trial is, and whether it could suit you

Intracerebral hemorrhage (ICH) is the second most common form of stroke, with an incidence of around 3000 cases per year in Hong Kong. Although it only accounts for around 20-30% of all strokes, ICH is the most severe form of stroke, contributing to 50% of all stroke mortality and the greatest disability burden in stroke. For those who survive their ICH, they are at high risk of ICH recurrence, stroke, cardiovascular event and death. Hence, reducing these risks after ICH is a top priority to lessen the disease's healthcare and social burden. Hypertension is the main driver for ICH, and achieving blood pressure (BP) control significantly reduces the risk of recurrent ICH, stroke and cardiovascular events. However, only 50% of ICH survivors achieved BP control after ICH. This is because ICH patients represent a unique hypertensive population with more difficult-to-control BPs, with many r

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. Spontaneous ICH 2. Age โ‰ฅ18 years 3. Premorbid modified Rankin Scale of โ‰ค3 4. TRICH score โ‰ฅ3 5. Within 1 week of ICH Exclusion Criteria: 1. Glasgow coma score \<9 2. Expected life expectancy of six months 3. Admission SBP \<160mmHg 4. Severe renal impairment, estimated glomerular filtration rate using CKD-EPI formula \<30 ml/min/1.73m2 5. Inability to perform home BP monitoring 6. Inability to participate in follow-up activity 7. Hypersensitivity to study drug 8. Known contraindication to amlodipine 9. Known contraindication to valsartan 10. Known contraindication to hydrochlorothiazide 11. Any conditions that investigator deems that patient is not suitable of any component of the triple pill or antihypertensive medications in general
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What it tests

  • Exforge HCTยฎ or Three Individual drug amlodipine + valsartan + hydrochlorothiazide
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Where

4 sites
Princess Margaret Hospital
Hong Kong, Hong Kong
Queen Mary Hospital
Hong Kong, Hong Kong
Ruttonjee Hospital
Hong Kong, Hong Kong
Yan Chai Hospital
Hong Kong, Hong Kong
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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