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"Effect of Ibuprofen on Acute Inflammatory Response After One-Stage Periodontal Therapy"

RecruitingPhase 4Ages 18 Years - anyAllUniversity of Baghdad
NCT07459049 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this ( Clinical Trial ) is to evaluate the efficacy of Ibuprofen in reducing acute inflammatory response (hs-CRP, ProCT, IL-6) after one hour and one week following one stage non surgical periodontal therapy. The main question it aims to answer is: "Does Ibuprofen effectively reduce the acute inflammatory response ( hs-CRP, ProCT, IL-6) following one-stage non-surgical periodontal therapy?"

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. systemically healthy patients. 2. having a minimum of 20 teeth. 3. Generalized unstable periodontitis. 4. Pocket depth \[≥ 4 mm\]. 5. All included participants should be adults aged more than 18 years . 6. smokers and non smokers Exclusion Criteria: 1. Allergy or hypersensitivity to Ibuprofen or other NSAIDs. 2. current systemic anti-inflammatory or antibiotic therapy (\<3 months). 3. peptic ulcer disease. 4. recent periodontal therapy (\<3 months). 5. Asthma. 6. Renal impairment . 7. Hepatic impairment. 8. Severe cardiac disease (heart failure, hypertension (. 9. Bleeding disorders (e.g., hemophilia) or patients taking anticoagulants . 10. Any participant who had known or suspected high risk for tuberculosis, hepatitis B or HIV infections. 11. pregnant or lactating females. 12. those being unable to provide written informed consent.
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What it tests

  • Non surgical root surface debridement in one stage without receiving Ibuprofen
  • Non surgical root surface debridement in one stage with receiving Ibuprofen
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Where

1 site
College of Dentistry, University of Baghdad
Baghdad, Iraq
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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