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Tranexamic Acid for Bleeding Reduction During TURP Surgery

RecruitingPhase 4Ages 50 Years - anyMaleHamza Najout
NCT07460518 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Transurethral resection of the prostate (TURP) is commonly performed in elderly patients and may be associated with perioperative bleeding leading to postoperative anemia and delayed recovery. Tranexamic acid (TXA), an antifibrinolytic agent, may reduce surgical bleeding by inhibiting fibrin degradation. This prospective randomized quadruple-blind placebo-controlled clinical trial evaluates whether perioperative administration of intravenous tranexamic acid reduces intraoperative blood loss and preserves postoperative hemoglobin concentration in patients undergoing TURP under standardized spinal anesthesia. Participants are randomly assigned to receive either intravenous tranexamic acid or placebo prior to surgery. The primary outcomes assess objective measures of perioperative blood loss and postoperative hemoglobin levels. Secondary outcomes include recovery parameters, perioperative

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male patients aged 50 years or older * Diagnosed with benign prostatic hyperplasia (BPH) * Scheduled for elective transurethral resection of the prostate (TURP) under spinal anesthesia * American Society of Anesthesiologists (ASA) physical status I-III * Provided written informed consent Exclusion Criteria: * History of thromboembolic disease (deep vein thrombosis, pulmonary embolism, stroke) * Known hypersensitivity to tranexamic acid * Severe renal impairment (creatinine clearance \<30 mL/min) * Coagulation disorders * Current anticoagulant therapy not appropriately discontinued * History of seizure disorder * Refusal to participate
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What it tests

  • Tranexamic Acid
  • Placebo (Normal Saline)
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Where

1 site
Mohammed V Military Teaching Hospital
Rabat, Morocco
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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