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Effect of Oxygen Administration in the Non-dependent Lung on Postoperative Complications After Lung Surgery

RecruitingPhase 4Ages 18 Years - anyAllFrancisco Andres de la Gala
NCT07461779 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to analyze the effectiveness of apneic oxygenation and CPAP applied to the non-dependent lung during pulmonary resection surgery in reducing inflammatory response, ischemia-reperfusion injury, and postoperative complications. We will conduct a randomized, controlled, and blinded study in 177 patients with three arms: * Control Group: Oxygen therapy according to standard clinical practice * Apneic oxygenation group: A probe will be introduced through the lumen of the double-lumen tube (DLT) to administer a continuous source of oxygen without any mechanism that generates airway pressure. * CPAP Group: Continuous positive airway pressure with 3-5 L/min oxygen flow and 2 cm H2O pressure delivered via a Mapleson system. Inflammatory mediators in blood and in both lungs will be measured intraoperatively and 24 hours after surgery. Patients will be followed from h

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients of both genders undergoing lung resection surgery in the Thoracic Surgery Department at Hospital General Universitario Gregorio Marañón * Lung isolation using a double-lumen tube (DLT) * Scheduled surgery * Patients able and willing to give written informed consent * Patients over 18 years old and legally competent Exclusion Criteria: * Patients with evidence of pulmonary bullae * Pregnancy or breastfeeding * Blood transfusion within 10 days prior to surgery * Treatment with immunosuppressants or corticosteroids within 3 months prior to surgery * Patient refusal to participate * Prior contralateral thoracic surgery * Robotic surgery * Pneumonectomy * Enrollment in another clinical trial
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What it tests

  • Medicinal gas - oxygen (Nippon Gases 200 bar)
  • CPAP
  • Oxygen therapy according to standard clinical practice
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Where

1 site
Hospital General Universitario Gregorio Marañón
Madrid, Spain
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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