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โ† Trials
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Dexmedetomidine for Improving Emergence Quality in Thyroid Surgery

RecruitingPhase 4Ages 18 Years - 65 YearsAllBach Mai Hospital
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In plain words

What the trial is, and whether it could suit you

Thyroid surgery requires smooth emergence from anesthesia to minimize coughing, hemodynamic fluctuations, and agitation during extubation, which may contribute to postoperative complications such as bleeding or cervical hematoma. Dexmedetomidine, a selective ฮฑ2-adrenergic receptor agonist, has sedative, analgesic-sparing, and sympatholytic properties that may improve anesthetic stability and recovery quality. This randomized controlled trial aims to evaluate the effectiveness of a continuous perioperative dexmedetomidine regimen initiated at induction of anesthesia and maintained during thyroid surgery. The study will compare dexmedetomidine combined with standard balanced anesthesia versus standard anesthesia alone in terms of anesthetic requirements and emergence quality. The primary hypothesis is that perioperative dexmedetomidine administration reduces anesthetic and opioid requir

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age 18-65 years. * American Society of Anesthesiologists (ASA) physical status I-III. * Scheduled for elective thyroid surgery (thyroidectomy) under general anesthesia with endotracheal intubation. * Able to understand the study procedures and provide written informed consent. Exclusion Criteria: * Known hypersensitivity or contraindication to dexmedetomidine or study-related medications. * Clinically significant cardiac conduction abnormality or arrhythmia (e.g., second- or third-degree atrioventricular block without a pacemaker), severe bradyarrhythmia, or unstable cardiovascular disease. * Severe hepatic dysfunction or severe renal failure. * Pregnancy or breastfeeding. * Planned postoperative ICU admission or postoperative deterioration requiring ICU admission. * Major intraoperative complications (e.g., major bleeding requiring urgent hemostatic intervention, tracheal or esophageal injury, or recurrent laryngeal nerve injury identified intraoperatively). * Any condition that, in the investigator's judgment, would interfere with outcome assessment or increase risk (e.g., inability to reliably report pain scores or complete QoR-15).
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What it tests

  • Dexmedetomidine
  • Standard General Anesthesia
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Where

1 site
Center for Anesthesia and Surgical Intensive Care, Bach Mai Hospital
Hanoi, Vietnam
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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