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Chinese Classics Recitation Training in Subjective Cognitive Decline

RecruitingNAAges 60 Years - anyAllChina Medical University Hospital
NCT07463391 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Subjective cognitive decline (SCD) is considered a preclinical condition associated with an increased risk of dementia and Alzheimer's disease. Effective early behavioral interventions remain limited, and the neurobiological mechanisms underlying cognitive training effects are not fully understood, particularly in culturally specific educational contexts. This randomized, assessor-blinded, controlled clinical trial will enroll 60 individuals with SCD to evaluate the effects of a six-month structured Chinese Classics recitation training program. Participants will be randomly assigned to either an intervention group or a non-active control group. Assessments will be conducted at baseline, immediately post-intervention, and during annual follow-up. Multimodal evaluations will include neuropsychological testing, functional magnetic resonance imaging (fMRI), electroencephalography (EEG), bl

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 60 years old * At least two "yes" responses to the following questions are required: 1. Forgetting where things are placed? 2. Unable to recall the names of good friends? 3. Unable to follow and recall conversation? 4. Subjective memory problems? 5. Consider own memory to be worse than others of a similar age? Exclusion Criteria: * Objective cognitive impairment defined as ≥ 1.5 standard deviations below standardized cognitive testing (e.g., MMSE) * Diagnosis of MCI * Clinical Dementia Rating (CDR) ≥ 0.5 * Diagnosis of major depressive disorder * Beck Anxiety Inventory score ≥ 16 * Other medical or neurological conditions that could explain cognitive decline (e.g., vascular dementia, traumatic brain injury) * Claustrophobia * Contraindications of MRI (e.g., non-MRI-compatible cardiac pacemaker or devices implanted within the past three months)
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What it tests

  • Memory training by Chinese Classics recitation
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Where

1 site
China Medical University Hospital
Taichung, Taiwan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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