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Evaluation of Positron Emission Tomography (PET) With [18F]FET for the Detection of ACTH-Secreting Corticotroph Pituitary Neuroendocrine Tumors.

Recruitingn/aAges 18 Years - anyAllHospices Civils de Lyon
NCT07463625 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cushing's disease results from adrenocorticotropic hormone (ACTH) secretion by corticotroph pituitary neuroendocrine tumors (PitNETs). Magnetic resonance imaging (MRI) is the reference modality for etiological diagnosis but may to visualize small corticotroph microadenomas in up to 30% of the cases, and false positives may occur. The study hypothesis is that positron emission tomography (PET) using \[18F\]fluoroethyl-L-tyrosine (\[18F\]FET) improves localization of ACTH-secreting corticotroph microadenomas compared with MRI and could inform surgical planning and reduce reliance on invasive inferior petrosal sinus sampling. This observational cohort (retrospective and prospective data) will assess the diagnostic performance of \[18F\]FET PET for tumor localization using postoperative histopathology as the gold standard. Secondary aims include: 1. assessing cases in which PET modifies

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adults (≥18 years). * Biochemical diagnosis of Cushing's disease as part of initial management. * Pituitary MRI performed; if visible, microadenoma \<10 mm in diameter. * Indication for discussion in multidisciplinary tumor board for surgical management. Exclusion Criteria: * Minor (age \<18 years). * Macroadenoma of the pituitary. * ACTH-dependent hypercortisolism secondary to ectopic secretion.
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What it tests

  • Data-only evaluation of [18F]FET PET, pituitary MRI, and biomarkers
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Where

1 site
Hôpital Louis Pradel - Service de Médecine Nucléaire
Bron, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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