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Transcriptomic Profile Changes in Benign Tracheal Stenosis: Wedge Resection vs. Radial Incision

RecruitingNAAges 18 Years - 80 YearsAllUniversity of Maryland, Baltimore
NCT07463742 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Some people develop a narrowing of their windpipe (trachea), called benign tracheal stenosis, which can make it hard to breathe. Doctors often treat this by using a bronchoscope-a thin, flexible tube with a camera-to open up the airway or remove scar tissue. While these procedures help patients breathe better, we do not fully understand why the narrowing occurs or how the tissue heals afterward. The purpose of this study is to better understand the biological changes in the airway tissue before and after these standard medical procedures. During the procedure, small samples of tissue that would already be collected as part of normal care will be analyzed in the laboratory. The results may help doctors learn more about airway healing and could guide better treatments in the future.

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📋 Eligibility rules (as published)
Inclusion Criteria: * symptomatic tracheal stenosis * idiopathic subglottic stenosis * iatrogenic tracheal stenosis from intubation or tracheostomy Exclusion Criteria: * positive ANA or ANCA * tracheal stenosis from infection, i.e. TB * tracheal stenosis with cartilage fracture * tracheal stenosis with malacia * tracheal stenosis from malignancy * tracheal stenosis from benign tumor * presence of glottic or supraglottic stenosis
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What it tests

  • Bronchoscopy, carbon dioxide (CO2) laser wedge resection
  • Radial incision with dilation
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Where

1 site
University of Maryland
Baltimore, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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