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Advanced Brain Imaging-TKA (fMRI-TKA)

RecruitingNAAges 18 Years - anyAllOttawa Hospital Research Institute
NCT07464080 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges. This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Male and female patients aged 18 years or older 2. Primary TKA 3. Diagnosis of osteoarthritis, inflammatory arthritis, or osteonecrosis Exclusion Criteria: 1. Inability or refusal to sign informed consent form 2. Non-English or French speaking, and no licensed translator, family member or substitute decision maker available 3. History of major neurological disorders (e.g traumatic brain injury, epilepsy, multiple sclerosis 4. Cognitive impairment or dementia 5. Revision and/or Bilateral TKA 6. Chronic Opioid use
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What it tests

  • fMRI Brain Scan
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Where

1 site
The Ottawa Hospital
Ottawa, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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