AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

โ† Trials
๐Ÿงช

Pharmacokinetic Analysis of Cefiderocol in Patients With Acute Burn Injuries

RecruitingPhase 4Ages 18 Years - 80 YearsAllUniversity of Tennessee
๐Ÿ’ฌ

In plain words

What the trial is, and whether it could suit you

Cefiderocol is a powerful, broad spectrum antibiotic approved to treat hospital-acquired or ventilator associated pneumonia and urinary tract infections. Although cefiderocol has labeled dosing recommendations, including augmented renal clearance, patients with burn injury remain an unstudied population at high risk for MDR pathogens. The primary objective of this study is to evaluate the pharmacokinetic principles of cefiderocol in patients after acute burn injury. Findings from this study will determine the dose and interval necessary to maintain therapeutic concentrations of cefiderocol in patients after burn injury for adequate bactericidal activity, prevention of resistance, and treatment outcomes.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * age โ‰ฅ 18 and โ‰ค 80 years old * estimated CLCR (eCLCR) โ‰ฅ 60 mL/min via Cockcroft-Gault equation Exclusion Criteria: * KDIGO classification โ‰ฅ 1 at day of screening * known HIV or HBV infection
๐Ÿ’Š

What it tests

  • Cefiderocol
๐Ÿ“

Where

1 site
Regional One Health
Memphis, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
๐Ÿ›ก๏ธ

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it โ€” not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use ยท Privacy