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โ† Trials
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A Study of ELA026 in Participants With Relapsed/Refractory (R/R) T/NK Cell Malignancies (TCMs)

RecruitingPhase 1Ages 18 Years - anyAllElectra Therapeutics Inc.
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In plain words

What the trial is, and whether it could suit you

This is a Phase 1, two-part, multicenter study to evaluate ELA026 in participants โ‰ฅ18 years old with relapsed/refractory TCM following any line of prior therapy who are eligible for investigational treatments.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Age โ‰ฅ18 years Participants with a confirmed histologic diagnosis of a TCM who are R/R following any line of prior therapy (participants with CTCLs should have received at least 2 prior lines of systemic therapy for R/R CTCL) and eligible for investigational therapies * Presence of measurable disease by clinical examination, radiologic imaging (computed tomography, magnetic resonance imaging, or whole body FDG-PET scans), and/or in bone marrow aspirate/biopsy * Eastern Cooperative Oncology Group performance score of โ‰ค2 * Anticipated life expectancy \>6 months per investigator judgment Exclusion Criteria: * Participants who are eligible for standard of care or approved therapeutic options for R/R TCMs with established clinical benefit * Organ dysfunction as defined in the protocol * Participants with hemophagocytic lymphohistiocytosis (HLH) based on HLH2004 diagnostic criteria * Participants receiving or planning to start immunotherapy or immune effector cell therapy (such as chimeric antigen receptor \[CAR\] T-cell therapy, T-cell engagers, or programmed cell death protein 1 \[PD1\]/programmed cell death ligand 1 \[PD-L1\] inhibitors) * Allogeneic hemopoietic stem cell transplant within 100 days prior to the first dose of ELA026 and currently receiving systemic immunosuppressive therapy * Women of childbearing potential who are planning to become pregnant or are breastfeeding during the conduct of the study, including 60 days after last dose of study drug * Male participants whose partners are women of childbearing potential and who are planning to become pregnant during the conduct of this trial by the male partner, including within 60 days after the last dose of study drug
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What it tests

  • ELA026
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Where

6 sites
Yale New Haven Hospital
New Haven, United States
Emory University Hospital
Atlanta, United States
START, Midwest
Grand Rapids, United States
Memorial Sloan Kettering
New York, United States
University Hospitals Cleveland Medical Center
Cleveland, United States
MD Anderson
Houston, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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