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Hemodynamic Effects of Intravenous Paracetamol in Patients Undergoing Emergency Laparotomy

RecruitingNAAges 21 Years - 65 YearsAllCairo University
NCT07466108 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Emergency laparotomy is a high-risk procedure often performed in patients with severe physiological derangements due to sepsis, making perioperative management challenging. Although multimodal analgesia is essential, options are often limited by factors such as hemodynamic instability, renal dysfunction, and coagulopathy. Intravenous paracetamol is commonly recommended for perioperative analgesia because of its opioid-sparing effect, but evidence suggests it may cause hypotension through peripheral vasodilation, particularly in critically ill patients. Most data on this effect come from observational studies, and evidence regarding its intraoperative hemodynamic impact remains limited.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Adult patients, ASA I-III undergoing emergency laparotomy Exclusion Criteria: * Severe cardiac morbidities (impaired contractility with ejection fraction \< 40%, heart block, arrhythmias, tight valvular lesions) * Hemodynamically unstable patients (defined as patients with MAP \< 65 mmHg or need vasopressor to maintain MAP\>65 mmHg). * Patients with high shock index (heart rate / systolic blood pressure \>1) * Pregnant or lactating women, * Allergy of any of the study drugs
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What it tests

  • Paracetamol (acetaminophen)
  • Placebo Control
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Where

1 site
Cairo University
Cairo, Egypt
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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