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L-serine and Strength Training in the Elderly

RecruitingNAAges 65 Years - 85 YearsAllUniversity of Vienna
NCT07466290 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study investigates whether taking the amino acid L-serine, either alone or in combination with targeted strength training, can have a positive effect on mental performance, brain function, and physical fitness in older people. Healthy, independent women and men aged 65 to 85 are eligible to participate. Participants will be randomly assigned to one of three groups: placebo, L-serine, or L-serine combined with strength training. Cognitive tests, physical performance tests, and blood and brain tests will be conducted over a period of 48 weeks. The aim is to gain a better understanding of how nutrition and exercise can contribute to healthy aging.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women between the ages of 65 and 85 * Mini-Mental-State \>23 * Independently mobile, without aids (walker, cane, etc.) Exclusion Criteria: * Chronic diseases that contraindicate medical training therapy * Regular strength training (\>1x/week) in the last 6 months before confinement * Frailty Index ≥ 3 * Lack of written consent to test physical performance * Regular use of Cortison-containing medications or Antibiotika * MR-specific exclusion criteria: claustrophobia, metal equipment or other magnetic Material in or on the body * Non-compliance with the study protocol: \<70% of the planned L-serine administration, \<70% of the strength training
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What it tests

  • Strength training
  • L-serine supplementation
  • Control (cornstarch)
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Where

1 site
NuTraLab
Vienna, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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