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Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation

RecruitingNAAges 30 Years - 59 YearsAllUniversitas Padjadjaran
NCT07467954 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin r

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female patients with skin aging classified as Glogau scale II-III * Age 30-59 years. Exclusion Criteria: * Pregnant or breastfeeding women. * Active smokers. * Individuals with high levels of sun exposure. * History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months. * Use of oral isotretinoin within the past six months. * Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks. * Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month. * Presence of active facial skin inflammation. * History of keloid formation. * History of allergy to topical lidocaine anesthesia.
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What it tests

  • Fractional CO₂ laser
  • Long-pulsed 1064-nm Nd:YAG laser
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Where

1 site
Hasan Sadikin General Hospital
Bandung, Indonesia
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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