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Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location

RecruitingNAAges 18 Years - anyFemaleUniversity of Pennsylvania
NCT07469605 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Infertility patients have a higher baseline risk of ectopic pregnancy compared to the general population. If an early pregnancy is not visible by ultrasound, patients with a pregnancy of unknown location (PUL) will undergo uterine aspiration (D\&C) in order to diagnose an ectopic pregnancy and/or treat an abnormal intrauterine pregnancy destined for miscarriage. If the pathologic specimen obtained after D\&C does not contain chorionic villi, the presumptive diagnosis of ectopic pregnancy is made and methotrexate therapy is typically recommended. In many institutions, a D\&C must be scheduled in the operating room so that it may be performed under anesthesia, potentially delaying the urgent treatment of ectopic pregnancy. Office hysteroscopy is a safe and well-tolerated means of evaluating the uterine cavity, though little literature exists supporting its use in the evaluation of PUL. Th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients 18 years of age and older * Patients undergoing care with (1) positive serum hcg and (2) abnormal hcg trend, as defined by \<50% rise in bHCG over 48h period, repeated across three lab values. * Patients with pregnancy via unassisted conception, conception after ovulation induction and/or intrauterine insemination, and/or embryo transfer * Well established pregnancy dating, either with known LMP, or dating by IUI or embryo transfer Exclusion Criteria: * Patients with known abnormal cavity (history of fibroids, septum, or uterine anomaly) * Patients who are hemodynamically unstable or with an acute abdomen
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What it tests

  • Hysteroscopy for diagnosis and treatment of pregnancy of unknown location
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Where

1 site
Penn Fertility Care
Philadelphia, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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