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Comparative Outcomes of Subtunical Microdissection and Grafting Versus Classical Plaque Incision and Grafting in Complex Peyronie's Disease

RecruitingNAAges 18 Years - anyMaleNamik Kemal University
NCT07470528 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical study is to compare two surgical techniques used for the treatment of complex Peyronie's disease. Peyronie's disease can cause penile curvature, deformity, and difficulties during sexual intercourse due to fibrotic plaques within the penile tunica albuginea. In patients with severe deformity, surgical correction is often required. The main question this study aims to answer is whether subtunical microdissection can provide effective correction of penile curvature while preserving erectile function when compared with the classical plaque incision and grafting technique. Participants with complex Peyronie's disease who require surgical correction will undergo either subtunical microdissection or classical plaque incision and grafting. In order to standardize the procedures, the same graft material will be used in both surgical techniques. A bovine pericardial gr

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📋 Eligibility rules (as published)
Inclusion Criteria: * \- Male patients aged 18 years or older * Diagnosis of Peyronie's disease with stable plaque and stable penile curvature for at least 3 months * Presence of complex Peyronie's disease including severe curvature, multiplanar deformity, hinge effect, hourglass deformity, or large plaques causing functional impairment * Patients requiring surgical correction with graft-based reconstruction * Ability to provide informed consent and comply with follow-up evaluations Exclusion Criteria: * Ossified Peyronie's plaques requiring plaque excision * Congenital penile curvature (congenital chordee) * Previous penile prosthesis implantation * Active phase Peyronie's disease with progressive curvature or penile pain * Severe erectile dysfunction not responsive to medical therapy * History of prior penile reconstructive surgery * Significant systemic illness preventing surgical treatment * Inability to complete postoperative follow-up assessments
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What it tests

  • Subtunical microdissection and grafting
  • Classic plaque Incision and Grafting
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Where

1 site
Tekirdag Namik Kemal University Faculty of Medicine Hospital
Tekirdağ, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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