Symptomatic and Systemic Atherosclerotic Plaque Activity in Patients With Peripheral Arterial Disease Using Novel Imaging

Inclusion Criteria: * Male or female aged \> 18 years * Symptomatic atherosclerotic peripheral artery disease; * Intermittent claudication; with ankle/arm blood pressure ratio \<0.90 or artery stenosis \>50% in addition to at least one of the following; * \>1 vascular bed affected by atherosclerosis * Diabetes * Heart failure * Chronic kidney disease (eGFR \< 60 mL/min/1.73 m2) * Rest pain or necrosis of limb or gangrene of limb * Revascularization defined as limb bypass surgery or endovascular revascularization procedures (irrespective of the specific device used), including percutaneous transluminal angioplasty/stent of iliac or infra-inguinal arteries or extra-anatomical bypass surgery * Leg or foot amputation for arterial vascular indications * Ability to give written or verbal informed consent Exclusion Criteria: * Contraindication to colchicine or iodinated contrast * Long term requirement for colchicine for another clinical indication * Active diarrhoea * Recent lower limb revascularisation for symptomatic disease (\<6 weeks) * Renal failure (glomerular filtration rate \<30 mL/min/1.73 m2) * Cirrhosis or severe chronic liver disease * Women who are pregnant or breast-feeding * Women of child-bearing potential not protected by reliable contraception or is planning conception during the study * Current or planned long term use of cyclosporine, verapamil, HIV protease inhibitors, azole antifungals, or macrolide antibiotics (apart from azithromycin) * Patients deemed unlikely to return for follow up * Life expectancy \<1 year * Inability or unwilling to give informed consent