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PARP (Poly (ADP-ribose) Polymerase) Inhibitor With or Without Angiogenesis Inhibitor in Homologous Recombination Deficient Primary Ovarian Cancer, Fallopian-Tube Cancer, or Primary Peritoneal Cancer

RecruitingPhase 2, Phase 3Ages 18 Years - 75 YearsFemaleN.N. Alexandrov National Cancer Centre
NCT07472140 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a randomized trial evaluating the results of using of PARP inhibitor combined with angiogenesis inhibitor. in patients with homologous recombination deficient primary ovarian cancer, fallopian-tube cancer, or primary peritoneal cancer of the III-IV stages.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18-≤75 years. * Histologically confirmed diagnosis of serous or endometrioid high-grade ovarian cancer, fallopian-tube cancer or primary peritoneal cancer. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Possibility of performing diagnostic laparoscopy or cytoreductive surgery. * Presence of homologous recombination deficiency (HRD). * No contraindications to chemotherapy, or bevacizumab. * Signed informed consent to participate in the study. Exclusion Criteria: * Presence of another active malignant invasive neoplasm. * Pregnancy or lactation period. * Disease progression during treatment.
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What it tests

  • PARP inhibitor + Bevacizumab
  • PARP inhibitor
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Where

1 site
N.N. Alexandrov National Caner Centre
Minsk, Belarus
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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