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Effect of Intraoperative Morphine on Postoperative Pain After CABG

RecruitingPhase 4Ages 18 Years - 80 YearsAllIstanbul University - Cerrahpasa
NCT07472959 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ethics committee approval was obtained for this study, which was planned as a prospective, randomized, controlled, single-center trial to be conducted in patients undergoing coronary artery bypass grafting (CABG) surgery between December 2025 and March 2026. Patients eligible for inclusion were randomized into two groups at a 1:1 ratio using a random number list generated via the random.org website. Randomization was performed by an independent investigator who was not involved in the study procedures. The allocation sequence was placed into sequentially numbered, opaque, sealed envelopes. Upon enrollment of each patient, the next numbered envelope was opened to determine group assignment. Patients who did not complete the study protocol or did not receive the allocated medication were excluded from the analysis, and a per-protocol analysis approach was applied. The randomization list

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📋 Eligibility rules (as published)
Inclusion Criteria: * patients aged 18 to 80 years * classified as American Society of Anesthesiologists (ASA) III * who are scheduled for elective coronary artery bypass grafting. Exclusion Criteria: * Chronic opioid use. * Severe liver or kidney disease. * History of alcohol or substance abuse. * Left ventricular ejection fraction below 40%. * Inability to be weaned from mechanical ventilation within 12 hours after completion of surgery. * Undergoing combined cardiac surgery, including valve procedures. * Requirement for intra-aortic balloon pump (IABP) support. * Surgery performed on a beating heart. * Emergency surgery. * Reoperation due to bleeding or other complications. * Refusal to participate in the study.
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What it tests

  • In this study, morphine administration, which is routinely and frequently used in our operating room for patients undergoing CABG, was applied as an additional intervention
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Where

1 site
Istanbul University -Cerrahpasa Institute of Cardiology
Istanbul, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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