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Thyroid Carcinoma in Cancer Patients Undergoing Radiotherapy

Recruitingn/aAges 10 Years - 43 YearsAllIRCCS Azienda Ospedaliero-Universitaria di Bologna
NCT07473518 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to define the optimal surveillance strategy for children exposed to radiotherapy by assessing the incidence, risk factors, and timing of thyroid nodules and differentiated thyroid cancer. It also investigates the genetic features of thyroid tumors in this population to identify predictive biomarkers of onset, malignancy, and aggressiveness. Ultimately, the goal is to support more personalized management, including tailored surgery and targeted therapies.

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📋 Eligibility rules (as published)
INCLUSION CRITERIA For the group of oncologic patients who underwent radiotherapy: * Radiotherapy for an oncologic condition performed between January 1, 1999, and December 31, 2018; * Age at the time of radiotherapy \< 18 years; * Follow-up of at least 4 years conducted at the Endocrine-Metabolic Diseases Program, Pediatric Unit, IRCCS AOU Bologna; * Obtained informed consent For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * No history of exposure to ionizing radiation; * No specific risk factors for DTC (autoimmune thyroiditis, familial forms, genetic syndromes); * Thyroid ultrasound performed between January 1, 1999, and December 31, 2018, at the Nuclear Medicine Unit of IRCCS AOU Bologna; * Age at the time of the thyroid ultrasound \< 18 years; * Obtained informed consent EXCLUSION CRITERIA: For the group of oncologic patients who underwent radiotherapy: * Patients transferred to another center before completing 4 years of follow-up after radiotherapy at the Pediatric Unit of IRCCS AOU Bologna, without having received a diagnosis of thyroid cancer. For the group of subjects not exposed to radiotherapy and without specific risk factors for DTC: * None.
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What it tests

  • Not listed
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Where

2 sites
UO Medicina Nucleare - IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
UOC Pediatria - IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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