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An Interventional Study to Evaluate the Impact of Blood Flow Restriction Training on Muscle, Bone, and Quality of Life in Adults With Osteogenesis Imperfecta Type I

RecruitingNAAges 18 Years - 65 YearsAllUniversity Hospital, Ghent
NCT07478224 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Due to fear of injury and risk of fractures, many people with osteogenesis imperfecta (OI) avoid vigorous exercise that is likely to improve muscle and bone weakness common in this disorder. Low-intensity muscle strength training with blood flow restriction (BFR-LI) via an inflatable cuff leads to similar improvements in muscle size and strength to conventional high-intensity strength training but has not been applied in OI.Objectives: To evaluate the effect of BFR-LI on muscle and bone health and quality of life in adults with OI type I.Methods: For this randomized controlled trial, 40 adults (18-65y) with OI type I will be recruited. Exclusion criteria include pregnancy or \<6 months postpartum, deep vein thrombosis, acute fractures, recent surgery, regular vigorous exercise, or contraindications to exercise. Participants will be randomly assigned to perform BFR-LI or stand

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📋 Eligibility rules (as published)
Inclusion Criteria: * Osteogenesis imperfecta type I, aged between 18 and 65 years old Exclusion Criteria: * Lower limbs: Edema; Recent surgery; Acute fractures * Pregnancy/\<6 months postpartum * Deep vein thrombosis (now or history of) * Cardiovascular, respiratory, or neuromuscular diseases * Recent cardiovascular events/untreated hypertension * Diseases affecting vascular function (e.g., diabetes) * Vigorous strength training in year before study * Other contraindications to perform exercise
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What it tests

  • Blood flow restriction training
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Where

1 site
Ghent University (Hospital) - department of endocrinology and department of rehabilitation sciences and physiotherapy
Ghent, Belgium
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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