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Progel Platinum for Air Leak Reduction After VATS Lobectomy for NSCLC

RecruitingNAAges 18 Years - 99 YearsAllFondazione del Piemonte per l'Oncologia
NCT07479277 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This multicenter randomized trial evaluates whether routine use of Progel Platinum surgical sealant on stapled fissure lines during VATS upper or lower lobectomy for NSCLC reduces pleural drainage duration compared with standard stapling alone. Secondary objectives include postoperative length of stay, incidence and duration of postoperative air leaks, residual pleural space, safety outcomes, and hospitalization costs.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 years * Written informed consent * Planned VATS upper or lower lobectomy for NSCLC * Minimally invasive thoracoscopic approach * Middle lobectomy excluded Exclusion Criteria: * Induction radiochemotherapy or chemo-immunotherapy * Severe COPD: GOLD 3 or higher * Sleeve resection or extended resection involving other lobes/chest wall/pericardium, etc. * Albumin intolerance/allergy * Renal insufficiency * Redo surgery * Use of sealants/adhesives other than the study approach * Expected extensive pleural adhesions
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What it tests

  • Progel Platinum
  • Mechanical Stapling
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Where

6 sites
Unità di Chirurgia Toracica Oncologica
Candiolo, Italy
Ospedale centrale di Bolzano, Chirurgia Toracica e Vascolare
Bolzano, Italy
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
Milan, Italy
Irccs Ismett
Palermo, Italy
Azienda Ospedaliera-Universitaria Pisana
Pisa, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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