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Effect of Local Use of Vitamin D on the Rate of Canine Distillization: a Split Mouth Randomized Control Trial

RecruitingPhase 1Ages 13 Years - anyAllFoundation University Islamabad
NCT07479290 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Orthodontic treatment (OT) is characterized as a lengthy procedure and enormous effort has been harnessed to shorten the OT duration using either surgical or non-surgical approaches. With the emerging concept of "accelerated orthodontics," scientific interest has been focused on chemical and electrical stimuli in combination with mechanical forces for rapid bone turnover and more stable results. Given the role of cytokines, parathyroid hormone, active vitamin D3 (1,25 dihydroxycholecalciferol) in bone regeneration, several studies have been conducted in which exogenous biological molecules have been locally administrated in order to stimulate orthodontic tooth movement. Vitamin D (Vit-D) plays a significant role in bone biology and remodeling.There are two primary forms of Vit-D: 25-OHD (25-hydroxyvitamin D) and 1,25 DHC (1,25-dihydroxycholecalciferol) which is the active form. 1,25 DH

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patient with permanent dentition * Angles class 1,class II dental malocclusion, indicated for bilateral maxillary first premolar extraction * minimum 5 of extraction space Exclusion Criteria: * several craniofacial deformities such as cleft lip and palate * history of bone disease such as osteoporosis or diabetes * pregnant and lactating women
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What it tests

  • Experimental: 1,25 DHC injection
  • Placebo: plain DMSO solvent
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Where

1 site
Foundation University Islamabad
Islamabad, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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