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Pv-aCO₂ Gap-Guided Resuscitation in Adult Polytrauma Patients: A Prospective Randomized Controlled Trial

RecruitingPhase 4Ages 18 Years - 70 YearsAllPakistan Institute of Medical Sciences
NCT07480655 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

dult patients with multiple traumatic injuries admitted to the ICU from the operating room, emergency department, or hospital wards who meet the study criteria will be included after obtaining informed consent from the patient or their legal guardian. Participants will be randomly divided into two groups: one group will receive treatment guided by the difference between carbon dioxide levels in venous and arterial blood, while the other group will receive treatment based on standard resuscitation parameters commonly used in critical care. As part of routine monitoring, all patients will have a central venous catheter and an arterial line inserted to measure blood parameters. Blood samples from both lines will be taken shortly after ICU admission and at regular intervals during the first three days. These samples will be analyzed using a bedside blood gas machine, and the results will be

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📋 Eligibility rules (as published)
Inclusion Criteria: * Either Gender * Poly-trauma patients ○ Both penetrating and blunt trauma * Both surgical and non-surgical * Shock States Exclusion Criteria: * Any Chest trauma * Patients with Obstructive and restrictive lung disease * Obstructive sleep apnea * Septic shock * Pregnant patients * Patients who will require readmission within 48 h after step-down from the ICU. * Patients who will need extra-corporeal membrane oxygenation support
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What it tests

  • Veno-arterial Carbondioxide gap
  • Conventional resuscitation end points
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Where

1 site
Department of Anesthesia, Pakistan Institute of Medical Sciences
Islamabad, Pakistan
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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