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SGLT2i Improve Left Atrial Function in Patients With Paroxysmal Atrial Fibrillation, Hypertension and Abnormal Glucose Metabolism

RecruitingPhase 2Ages 18 Years - 80 YearsAllHuashan Hospital
NCT07482020 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Heart failure is the most important clinical endpoint event in atrial fibrillation (AF). Patients with AF complicated by heart failure have a significantly higher risk of all-cause mortality and cardiovascular mortality compared to those without heart failure. Abnormal left atrial function is an important mechanism leading to the occurrence of AF-related heart failure. Therefore, it is essential to find drugs that can improve left atrial function to prevent heart failure in patients with AF. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are important drugs for regulating metabolic abnormalities. Studies have found that these drugs also reduce the risk of new-onset AF in patients with heart failure. Thus, the investigators hypothesize that SGLT2i may be able to regulate left atrial function. This study is a multicenter randomized controlled trial using three-dimensional speckle trac

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📋 Eligibility rules (as published)
Inclusion Criteria: * • Patients aged 18-80 years, treated in the outpatient or inpatient departments of each research center and included in the AF database. * Patients with paroxysmal AF confirmed by 12-lead electrocardiogram, 24-hour Holter monitoring, or handheld electrocardiogram devices. * Patients with hypertension who have already started antihypertensive treatment. * Patients with diabetes who have already started antidiabetic treatment, or patients with prediabetes who have not received antidiabetic treatment but have an HbA1c level within the range of 6.1-6.4% in the past three months. Exclusion Criteria: * • Atrial fibrillation caused by severe mitral stenosis. * Atrial fibrillation with severe mitral regurgitation and severe tricuspid regurgitation. * Patients who have been clinically diagnosed with heart failure (heart failure with preserved ejection fraction or heart failure with reduced ejection fraction). * Special types of cardiomyopathy: amyloid cardiomyopathy, Fabry disease, muscular dystrophy, hypertrophic obstructive cardiomyopathy, etc. * Patients with a history of myocardial infarction within the past three months. * Pregnant women.
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What it tests

  • SGLT-2 inhibitors
  • Placebo
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Where

1 site
Fudan University Affiliated Huashan Hospital, Cardiology Department
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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