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fNIRS for Disorders of Consciousness

Recruitingn/aAges 18 Years - anyAllUniversity of California, Los Angeles
NCT07485361 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care unit (Neuro-ICU). DoC include conditions such as coma and minimally conscious state that occur after severe brain injury. These conditions make it difficult to assess a person's level of awareness because many clinical tests rely on observable behaviors such as speaking or moving, which are commonly impaired after brain injury. The main questions the study aims to answer are: * Can fNIRS detect changes in brain activity in healthy adults when they receive sensory stimulation or perform mental tasks? * Can the same fNIRS protocol be used in patients with disorders of consciousness in the Neuro-ICU to measure brain responses and determine whether the method is fea

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📋 Eligibility rules (as published)
Inclusion Criteria: Healthy Control Participants: * Age 18 years or older * Proficient in English language * Intact cognition * Montreal Cognitive Assessment (MoCA) score \> 26 DoC Patients: * Age 18 years or older * Proficient in English language * Surrogate decision maker available * Admission to the intensive care unit within 28 days * Documented Glasgow Coma Scale (GCS) score * Auditory Function subscale score ≥1 on the Coma Recovery Scale-Revised (CRS-R) Exclusion Criteria: Healthy Control Participants: * Known baseline hearing impairment without available hearing aids * Neurological or psychiatric history DoC Patients: * Known baseline hearing impairment without available hearing aids * Inability to obtain informed consent * Extensive bilateral frontal injury on available imaging (CT/MRI) * Patients who have undergone craniectomy surgery * IV sedation in the past 24 hours * Absent auditory startle response (\<1 from Auditory Function subscale score of CRS-R)
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What it tests

  • Functional Near-Infrared Spectroscopy Monitoring
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Where

1 site
UCLA School of Nursing; Ronald Reagan Medical Center
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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