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Emapalumab MDA5 Rapidly Progressive Interstitial Lung Disease (RP-ILD) Study

RecruitingPhase 2Ages 18 Years - anyAllUniversity of Miami
NCT07486869 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a proof of concept study to determine if Emapalumab appears effective for the treatment of anti-MDA5 antibody positive rapidly progressive interstitial lung disease (MDA5 RP-ILD). Emapalumab is a medication that is currently used for a severe problem with the immune system, called macrophage activation syndrome, and this disease shares some similar features with MDA5 RP-ILD.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Progressive interstitial lung disease as determined by at least 2/4 of the following: 1. worsening respiratory symptoms; 2. worsening or new oxygen requirement; 3. worsening disease on CT chest; 4. worsening Forced Vital Capacity (FVC1) or Diffusing Capacity for Carbon Monoxide (DLCO) on pulmonary function tests * MDA5 antibodies present * Elevated ferritin above the upper limit of normal (ULN) * Participant at least 18 years old Exclusion Criteria: * Active, untreated bacterial, mycobacterial or fungal infection * Active herpes zoster infection * Currently requiring extracorporeal membrane oxygenation (ECMO) * Participant refusal to participate in the study * Pregnant women * Prisoners
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What it tests

  • Emapalumab
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Where

1 site
University of Miami Hospital and Clinics
Miami, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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