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Single-cell and Spatial Transcriptomic Profiling of Gingival Tissues in Aggressive and Chronic Periodontitis: Deciphering Cellular Heterogeneity and Inflammatory Microenvironment Features

Recruitingn/aAges 20 Years - 40 YearsAllSecond Affiliated Hospital, Zhejiang University, …
NCT07487272 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this observational study is to investigate cellular heterogeneity and inflammatory microenvironment features in gingival tissues from patients with aggressive periodontitis compared to chronic periodontitis and healthy controls, using single-cell and spatial transcriptomics combined with whole-genome sequencing. The main question(s) it aims to answer are: What are the differences in cellular composition, mesenchymal stem cell subpopulations, and gene expression profiles between aggressive periodontitis, chronic periodontitis, and healthy gingival tissues? Which key molecular markers, signaling pathways, and spatially resolved microenvironment patterns distinguish aggressive periodontitis from the more common chronic form? Are there disease-specific genetic variants associated with aggressive periodontitis identified through whole-genome sequencing of peripheral blood DNA?

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📋 Eligibility rules (as published)
Inclusion Criteria: Aggressive Periodontitis Patients: 1. Aged 20-35 years 2. Radiographic evidence of at least 30% vertical bone loss at ≥2 tooth sites 3. Can be classified as Stage III/IV, Grade C periodontitis according to the 2018 new classification of periodontitis 4. With or without family history of periodontitis 5. No significant local contributing factors (e.g., calculus, occlusal trauma, etc.) Chronic Periodontitis Patients: 1. Aged 30-40 years 2. ≥3 sites with probing depth ≥5 mm 3. Can be classified as Stage I/II, Grade A/B periodontitis according to the 2018 new classification of periodontitis 4. No significant family history 5. Disease predominantly driven by local factors (dental plaque, calculus, etc.) Healthy Controls: 1. Aged 20-40 years 2. Radiographic examination shows no significant alveolar bone loss 3. Clinically cannot be diagnosed with gingivitis or periodontitis Exclusion Criteria: 1. Use of antibiotics within the past 3 months 2. Smoking \>10 cigarettes per day 3. Uncontrolled severe diabetes (HbA1c level ≥6.7%) 4. Planning pregnancy, currently pregnant, or breastfeeding 5. Alcohol or drug addiction 6. Long-term use of immunosuppressive agents 7. Infectious diseases such as hepatitis or AIDS/HIV 8. History of malignant tumor, radiotherapy, or chemotherapy within the past 5 years
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What it tests

  • Not listed
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Where

1 site
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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