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Conduction System Pacing vs. Biventricular Pacing for Cardiac Resynchronization Therapy

RecruitingNAAges 18 Years - 99 YearsAllCopenhagen University Hospital, Rigshospitalet
NCT07492979 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The NORDIC-CSP trial is an investigator-initiated, blinded, nordic RCT aimed at evaluating whether using direct pacing of the HIS bundle (HIS)-pacing or left bundle branch (LBB) pacing is superior to conventional biventricular pacing in reducing the incidence of the composite endpoint of death and non-planned HF hospitalization. The study will be conducted in the 4 CRT-centres in Denmark and 6-8 centres from countries Sweden, Norway and Finland.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≥18 years of age, * LVEF ≤ 35%, * NYHA Class II-IV (IV only outpatients), * optimized in medical treatment (OMT) AND one of the following: . LBBB according to AHA/ACC/HRS Scientific Statement from 2009 and ≥130ms or * LBBB-like intraventricular conduction delay (IVCD) \> 150ms or RV paced QRS and indication for upgrade to CRT (\> 40% RV pacing) OR * ≥18 years of age, * LVEF ≤ 40 % * pacing indicated by AV-block and, thus, expected large percentage of ventricular pacing. Exclusion Criteria: * recent acute myocardial infarction (AMI) * coronary artery bypass graft (CABG) (\<3 months) * life expectancy \<2 years, patients in hemodialysis * treatment with a cardiac implantable electronic device (CIED) is contraindicated. * Patients are excluded with regards to the MRI sub study if eGFR \> 35 ml/min, in case or contrast allergy or certain metal implants.
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What it tests

  • HIS or LBBB -CRT
  • Conventional BiV-CRT
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Where

5 sites
Dept. of Cardiology, Aarhus University Hospital, Aarhus
Aarhus, Denmark
Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmark
Dept of Cardiology, Meilahti Hospital, Helsinki
Helsinki, Finland
Haukeland Universitetssykehus
Bergen, Norway
Sahlgrenska University Hospital
Gothenburg, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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