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Safety of a Healthy Plant-based Diet With Higher Potassium Content, Compared to a Healthy Plant-based Diet With Limited Potassium Content in Patients With Chronic Kidney Disease: A Pilot Study

RecruitingNAAges 20 Years - 85 YearsAllKarolinska Institutet
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In plain words

What the trial is, and whether it could suit you

For many years, people with moderate to advanced chronic kidney disease (CKD) have been advised to limit their intake of potassium, a mineral found in many foods such as fruit, vegetables, legumes, whole grains, and nuts. The reason for this has been the risk of hyperkalemia, a condition in which the potassium level in the blood becomes too high and can be dangerous. In recent years, however, this view has been questioned. New research suggests that the link between potassium in food and high potassium levels in the blood may not be as clear as previously thought. People who follow a strict potassium-restricted diet experience a lower quality of life and less satisfaction with their dietary treatment. At the same time, they miss out on the health benefits of eating a varied and nutritious diet. Today, many experts advocate a more individualized approach to potassium intake: instead of g

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria * Age between 20 and 85 years * Chronic kidney disease (CKD) with an estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73 mยฒ * Normal potassium levels (plasma potassium 3.5-5.3 mmol/L) * Not on dialysis * Good knowledge of Swedish Exclusion Criteria * Pregnancy * Breastfeeding * Kidney transplant * Regular use of potassium binders at least 4 days/week (e.g. sodium zirconium cyclosilicate, patiromer or sodium polystyrene sulfonate) * Regular prescription of daily potassium salts (e.g. potassium chloride) * Planned kidney transplant * Planned start of dialysis within the next 6 months * Allergy to nuts (including peanuts) * Mental illness and cognitive impairment that impede understanding of dietary advice * Comorbidities that may affect potassium balance (e.g. adrenal insufficiency, inflammatory bowel disease, chronic diarrhoea or colostomy)
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What it tests

  • Healthy plant-based diet (healthy-PBD)
  • Potassium-restricted plant-based diet
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Where

1 site
Karolinska Institute
Huddinge, Sweden
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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